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Haplophyllum tuberculatum: An important medicinal plant in Sistan and Baloochestan province, Iran

نوع فایل:PDF

تعداد صفحات:9

سال انتشار:1395

چکیده

The genus Haplophyllum belonging to the Rutaceae family distributedfrom the Mediterranean area to eastern Siberia. This genus consists of22 species widespread in the Asia to N. Africa. Among the 18 speciespresent in Iran, 9 species is endemic. Haplophyllum tuberculatum isdistributed in regions of central to south-eastern of Iran. The Persianname of this plant is Sodaby and its Baluchi name is Sadaap . It isused in traditional medicine as an antispasmodic, to treat allergicrhinitis and gynecological disorders, asthma and breathing difficulties,and in Baloochestan it is use by women for healing after childbirthailments. This plant is rich from Alkaloids, Lignanes, Glycosides andFlavonoids, etc. The major compounds of this plant are two Alkaloidsnamed Haplophytin-A and B, and the major compounds of essential oilare cis-p-menth-2-en-1-ol and trans-p-menth-2-en-1-ol

واژگان کلیدی

Haplophyllum tuberculatum, Medicinal plant, Sistan andBaloochestan

Functional Exposed Amino Acids of LamB as a vaccine candidate for Vibriosis

نوع فایل:PDF

تعداد صفحات:13

سال انتشار:1395

چکیده

Vibriosis is one of the most serious infectious diseases in fish and shellfish. However, due to the diversity of pathogens and their complicated serotypes, the progress in vaccine development against Vibriosis has been slow. LamB proteins (or maltoporins) are a family of OMPs. It forms a betabarrel composed of three monomers and ensures the transport of maltose and maltodextrin in Gram-negative bacteria reported that recombinant Aeromonas hydrophila outer membrane protein 48, which belongs to the maltoporin group of porins, induces a protective immune response against A. hydrophila and E. tarda. Findings indicated that antibodies against LamB were protective, making this antigen a likely candidate for a vaccine. Early clinical trials demonstrated that recombinant LamB was immunogenic and well tolerated, even in subjects with a history of vibrio disease. The present study was designed to in silico resolving the major obstacles in the control or in prevention of vibrio diseases. We exploited bioinformatic tools to better understanding and characterizing the LamB structure and select appropriate regions as effective B cell epitops

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زینب یکشنبه 10 اردیبهشت 1396 ساعت 06:22